Pooled Sputum for Xpert MTB/RIF Testing: A Cost-Saving Strategy in Mwanza, Tanzania
نویسندگان
چکیده
Background: Tuberculosis (TB) diagnostics, such as Xpert MTB/RIF, is still limited by cost. Testing of pooled samples from presumptive TB patients has been thought a cost-saving strategy to diagnose TB. We assessed the utility and MTB/RIF testing for diagnosis in Mwanza, Tanzania. Methods: Sputum Presumptive were submitted laboratory routine using MTB/RIF. The results individual sputum used reference standard concealed investigating technicians. remainder collected serially (5 per pool) testing. agreement between sample against cost-savings was assessed. Results: A total 250 analyzed 50 pools made with each pool containing 5 samples. Of made, Mycobacterium tuberculosis (MTB) detected 17 (34.0%) pools. Results retrieved all there 28 (11.2%) which MTB whereas 222 (88.8%) had no detected. Following re-analysis positive pools, (100%) within 1 3 pool. correctly identified on testing, sensitivity 100% specificity 100%. Using pooling strategy, we saved 46.0% (115/250) cartridges. Conclusion: reduced cartridge costs potential increase affordability countries resources,
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ژورنال
عنوان ژورنال: Advances in Infectious Diseases
سال: 2023
ISSN: ['2164-2656', '2164-2648']
DOI: https://doi.org/10.4236/aid.2023.132017